Phenotyping in the Mouse Embryo using a μMRI atlas
نویسندگان
چکیده
J. O. Cleary*, M. Modat*, A. N. Price, N. D. Greene, D. L. Thomas, P. J. Scambler, R. J. Ordidge, S. Ourselin, and M. F. Lythgoe Centre for Advanced Biomedical Imaging, Department of Medicine and Institute of Child Health, University College London, London, United Kingdom, Department of Medical Physics and Bioengineering, University College London, London, United Kingdom, Centre for Medical Image Computing, University College London, London, United Kingdom, Neural Development Unit, UCL Institute of Child Health, London, United Kingdom, Wellcome Trust Advanced MRI Laboratory, University College London, London, United Kingdom, Molecular Medicine Unit, UCL Institute of Child Health, London, *equal contribution
منابع مشابه
Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model
PURPOSE Advanced methodologies for visualizing novel tissue contrast are essential for phenotyping the ever-increasing number of mutant mouse embryos being generated. Although diffusion microscopic MRI (μMRI) has been used to phenotype embryos, widespread routine use is limited by extended scanning times, and there is no established experimental procedure ensuring optimal data acquisition. ME...
متن کاملFully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome
We describe a fully automated pipeline for the morphometric phenotyping of mouse brains from μMRI data, and show its application to the Tc1 mouse model of Down syndrome, to identify new morphological phenotypes in the brain of this first transchromosomic animal carrying human chromosome 21. We incorporate an accessible approach for simultaneously scanning multiple ex vivo brains, requiring only...
متن کاملμMRI Optimisation for Phenotyping the Embryo Mouse Heart
J. O. Cleary, A. N. Price, D. L. Thomas, P. J. Scambler, V. Kyriakopoulou, R. J. Ordidge, and M. F. Lythgoe Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, Department of Medical Physics and Bioengineering, University College London, London, United Kingdom, Wellcome Trust Advanced MRI Laboratory, University College London, London, United Kingdom, Molecu...
متن کاملDev107722 1..9
The International Mouse Phenotyping Consortium (IMPC) plans to phenotype 20,000 single-gene knockout mice to gain an insight into gene function. Approximately 30% of these knockout mouse lines will be embryonic or perinatal lethal. The IMPC has selected threedimensional (3D) imaging to phenotype thesemouse lines at relevant stages of embryonic development in an attempt to discover the cause of ...
متن کاملDev107722 2533..2541
The International Mouse Phenotyping Consortium (IMPC) plans to phenotype 20,000 single-gene knockout mice to gain an insight into gene function. Approximately 30% of these knockout mouse lines will be embryonic or perinatal lethal. The IMPC has selected threedimensional (3D) imaging to phenotype thesemouse lines at relevant stages of embryonic development in an attempt to discover the cause of ...
متن کامل